95SEASONAL VARIATION IN HEPATOPROTECTIVE ACTIVITY OF CASSIA ALATA LINN. LEAVES ON ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN RATSCassia alata Linn. is abundant in Sikkim and Darjeeling Himalayas in the middle and upper hill forest up to the height of 2000- 5000 ft. It is a medicinal plant traditionally used to treat a wide range of diseases. Hepatoprotective activity of Cassia alata Linn. has been noted in hepatotoxicity in rats. Seasonal variation in this effect, if any, was studied. Results showed that Cassia alata Linn. leaves during the period May – June had maximum protective effect on anti tubercular drugs induced hepatotoxicity in rats. dr_pkmitra@rediffmail.comResearch612016Cassia alata Linn,Hepatotoxicity,Anti-tubercular drugsPrasenjit Mitra, Tanaya Ghosh,Prasanta Kumar MitraDepartment of Biochemistry, North Bengal Medical College, Sushrutanagar – 734012 Dist. Darjeeling, West Bengal, India.,Department of Biochemistry, North Bengal Medical College, Sushrutanagar – 734012 Dist. Darjeeling, West Bengal, India., Professor & Head, Department of Medial Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.