21EVALUATION OF SOLUBILITY OF FLUTAMIDE BY USING SUPRAMOLECULAR TECHNIQUEThe poor aqueous solubility of flutamide gives raise to difficulties in pharmaceutical formulations for oral delivery, which may lead to poor bioavailability. To overcome this drawback, increasing the aqueous solubility of flutamide is an important goal. The present investigation deals with the approach of enhancement of flutamide by using a conformer tartaric acid and nicotinic acid utilizing a supramolecular technique. Moreover the study also determines the effect of solvent and the method influence the solubility and dissolution competence of flutamide. The solubility of the prepared co crystals enhanced the solubility in distilled water and pH6.8 phosphate buffer when compared to pure drug. From Invitro dissolution studies it shows increase in its dissolution profile of flutamide in water and pH 6.8 phosphate buffer compared to pure drug. From this study it can be concluded that by using supramolecular technique it is possible to enhance the solubility o f the poorly soluble drugs.ktvanan2006@yahoo.co.inResearch312013Flutamide, Supramolecular technique,Invitro dissolution studiesK.Thamizhvanan,S.Umakrithika,K.Vijayashanthi,Shaik Shaheen, K.Nandini,T.Syeeda Aisha,J.M.Sateesh BabuDepartment of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.,Department of Pharmaceutical Biotechnology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.